Physiological Intracytoplasmic Sperm Injection

While standard ICSI increases the chances of successful fertilization, PICSI takes this a step further by allowing the embryologist to choose the best quality, most mature sperm.

Sperm are introduced to hyaluronan (HA) hydrogel in the lab, mimicing the natural environment sperm would typically have to HA in a woman’s cervix.  Sperm naturally penetrate the cervical mucus in order for fertilization to occur. With PICSI, the embryologist is able to recreate these conditions by adding HA to the dish the sample of sperm has been placed in. Sperm that binds to the HA

With PICSI, the embryologist is able to recreate these conditions by adding HA to the dish the sample of sperm has been placed in. Sperm that binds to the HA are selected by the embryologist for ICSI. Studies have shown there is better embryo development when sperm bound to HA was used.